Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse

Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse

Phosphorodiamidate morpholino oligonucleotide (PMO)-based antisense reagents cannot enter cells without the help of a delivery technique, which limits their clinical applications. To overcome this problem, self-transfecting guanidinium-linked morpholino (GMO)-PMO or PMO-GMO chimeras have been explor...

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Bibliographic Details
Main Authors: Ujjal Das, Jayanta Kundu, Pallab Shaw, Chandra Bose, Atanu Ghosh, Shalini Gupta, Sudipta Sarkar, Jhuma Bhadra, Surajit Sinha
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
morpholino chimera
self-transfecting antisense
hedgehog signaling
zebrafish
NANOG
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000707

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http://www.sciencedirect.com/science/article/pii/S2162253123000707

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