The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.

The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.

BACKGROUND:Osteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metalloproteinases (MMPs)...

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Bibliographic Details
Main Authors: Laura Pérez-Is, Marcos G Ocaña, A Hugo Montes, José A Carton, Victoria Álvarez, Álvaro Meana, Joshua Fierer, Eulalia Valle-Garay, Víctor Asensi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0220022

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https://doi.org/10.1371/journal.pone.0220022

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