Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer’s Disease in Electronic Health Records

Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer’s Disease in Electronic Health Records

Alzheimer’s disease (AD) is the most common form of dementia and a growing public health burden in the United States. Significant progress has been made in identifying genetic risk for AD, but limited studies have investigated how AD genetic risk may be associated with other disease conditions in an...

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Bibliographic Details
Main Authors: Mingzhou Fu, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Timothy S. Chang, Anna L. Antonio, Maryam Ariannejad, Angela M. Badillo, Brunilda Balliu, Yael Berkovich, Michael Broudy, Tony Dang, Chris Denny, Eleazar Eskin, Eran Halperin, Brian L. Hill, Ankur Jain, Vivek Katakwar, Clara Lajonchere, Clara Magyar, Sheila Minton, Ghouse Mohammed, Ariff Muhamed, Pabba Pavan, Michael A. Pfeffer, Nadav Rakocz, Akos Rudas, Rey Salonga, Timothy J. Sanders, Paul Tung, Vu Vu, Ailsa Zheng, Ruth Jhnson, Yi Ding, Alec Chiu, Jae-Hoon Sul, Sriram Sankraraman, Bogdan Pasaniuc
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
polygenic risk score
phenome-wide association study
electronic health record
Mendelian randomization
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.800375/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.800375/full

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