Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction

Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction

BackgroundPhosphorylation of diacylglycerol by diacylglycerol-kinases represents a major inhibitory event constraining T cell activation upon antigen engagement. Efficient TCR signalling requires the inhibition of the alpha isoform of diacylglycerol kinase, DGKα, by an unidentified signalling pathwa...

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Bibliographic Details
Main Authors: Suresh Velnati, Sara Centonze, Giulia Rossino, Beatrice Purghè, Annamaria Antona, Luisa Racca, Sabrina Mula, Elisa Ruffo, Valeria Malacarne, Mario Malerba, Marcello Manfredi, Andrea Graziani, Gianluca Baldanzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
DGK diacylglycerol kinase
WAS (Wiskott-Aldrich syndrome)
T cell receptor signalling
SLAM-associated protein (SAP)
restimulation-induced cell death
X-linked lymphoproliferative disease (XLP)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1043603/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1043603/full

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