Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease

Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease

Background: Education and cognition demonstrate consistent inverse associations with Alzheimer’s disease (AD). The biological underpinnings, however, remain unclear. Blood metabolites reflect the end point of biological processes and are accessible and malleable. Identifying metabolites with etiolog...

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Bibliographic Details
Main Authors: Jodie Lord, Rebecca Green, Shing Wan Choi, Christopher Hübel, Dag Aarsland, Latha Velayudhan, Pak Sham, Cristina Legido-Quigley, Marcus Richards, Richard Dobson, Petroula Proitsi
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Biological Psychiatry Global Open Science
Subjects:
Biomarkers
Causality
Mediation
Mendelian randomization
Polygenic scores
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174321000872

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http://www.sciencedirect.com/science/article/pii/S2667174321000872

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