Analytical Techniques for the Assessment of Drug-Lipid Interactions and the Active Substance Distribution in Liquid Dispersions of Solid Lipid Microparticles (SLM) Produced de novo and Reconstituted from Spray-Dried Powders

Analytical Techniques for the Assessment of Drug-Lipid Interactions and the Active Substance Distribution in Liquid Dispersions of Solid Lipid Microparticles (SLM) Produced de novo and Reconstituted from Spray-Dried Powders

Solid lipid microparticles (SLM) can be presented as liquid suspension or spray-dried powder. The main challenge in SLM technology is to precisely determine the location of the active substance (API) in the different compartments of the formulation and its changes during SLM processing. Therefore, t...

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Bibliographic Details
Main Authors: Eliza Wolska, Małgorzata Sznitowska, Katarzyna Krzemińska, Maria Ferreira Monteiro
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
cyclosporine
spironolactone
solid lipid microparticles
DSC
AFM
Raman spectroscopy
Online Access:https://www.mdpi.com/1999-4923/12/7/664

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https://www.mdpi.com/1999-4923/12/7/664

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