Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice

Abstract Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, and can be observed during the prodromal phase of Parkinson’s disease (PD). However, the mechanism underlying these pathophysiological changes remains to be elucidated. Mutations in vacu...

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Bibliographic Details
Main Authors: Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S. Moehle, Habibeh Khoshbouei, Matthew J. Farrer
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00609-7

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https://doi.org/10.1038/s41531-023-00609-7

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