Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

AbstractBackground COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is a master transcription factor involved in the cellular response to oxygen levels. The immunopathogenesis of this...

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Main Authors: Keiko Taniguchi-Ponciano, Eduardo Vadillo, Héctor Mayani, César Raúl Gonzalez-Bonilla, Javier Torres, Abraham Majluf, Guillermo Flores-Padilla, Niels Wacher-Rodarte, Juan Carlos Galan, Eduardo Ferat-Osorio, Francisco Blanco-Favela, Constantino Lopez-Macias, Aldo Ferreira-Hermosillo, Claudia Ramirez-Renteria, Eduardo Peña-Martínez, Gloria Silva-Román, Sandra Vela-Patiño, Carlos Mata-Lozano, Roberto Carvente-Garcia, Lourdes Basurto-Acevedo, Renata Saucedo, Patricia Piña-Sanchez, Antonieta Chavez-Gonzalez, Daniel Marrero-Rodríguez, Moisés Mercado
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Annals of Medicine
Subjects:
COVID-19
SARS-CoV-2
critically ill
scRNAseq
HIF1α
immature myeloid cells
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2020.1858234

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https://www.tandfonline.com/doi/10.1080/07853890.2020.1858234

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