Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL

Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL

Abstract Background Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-chain gene has emerged as a highly sensitive method to detect minimal residual disease (MRD) in B acute lymphoblastic leukemia/lymphoma (B-ALL). However, a sensitive and easily implemented NGS methodology for...

Full description

Bibliographic Details
Main Authors: Shuhua Cheng, Giorgio Inghirami, Shuo Cheng, Wayne Tam
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Hematology & Oncology
Subjects:
NGS
MRD surveillance
B lymphoblastic leukemia/lymphoma
Relapse
Post-remission setting
Online Access:http://link.springer.com/article/10.1186/s13045-018-0652-y

Internet

http://link.springer.com/article/10.1186/s13045-018-0652-y

Similar Items