Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

To examine the normal cellular function of tau and its role in pathogenesis, we have created transgenic mice that overexpress a tau transgene derived from a human PAC that contains the coding sequence, intronic regions, and regulatory regions of the human gene. All six isoforms of human tau are repr...

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Bibliographic Details
Main Authors: K. Duff, H. Knight, L.M. Refolo, S. Sanders, X. Yu, M. Picciano, B. Malester, M. Hutton, J. Adamson, M. Goedert, K. Burki, P. Davies
Format: Article
Language:English
Published: Elsevier 2000-04-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902796

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http://www.sciencedirect.com/science/article/pii/S0969996199902796

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