Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

To examine the normal cellular function of tau and its role in pathogenesis, we have created transgenic mice that overexpress a tau transgene derived from a human PAC that contains the coding sequence, intronic regions, and regulatory regions of the human gene. All six isoforms of human tau are repr...

Full description

Bibliographic Details
Main Authors:	K. Duff, H. Knight, L.M. Refolo, S. Sanders, X. Yu, M. Picciano, B. Malester, M. Hutton, J. Adamson, M. Goedert, K. Burki, P. Davies
Format:	Article
Language:	English
Published:	Elsevier 2000-04-01
Series:	Neurobiology of Disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996199902796

Similar Items

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
by: Lorenzo M. Refolo, et al.
Published: (2000-12-01)

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
by: Lorenzo M. Refolo, et al.
Published: (2000-08-01)

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease
by: L.M. Refolo, et al.
Published: (2001-10-01)

Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
by: Sefika Ozcelik, et al.
Published: (2013-01-01)

Piericidin A aggravates Tau pathology in P301S transgenic mice.
by: Matthias Höllerhage, et al.
Published: (2014-01-01)

Unexpected Transcription of Human t-PA cDNA in transgenic tobacco plants
by: Mokhtar jalali, et al.
Published: (2011-05-01)

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
by: Carmen Romero-Molina, et al.
Published: (2018-11-01)

Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.
by: Peters, O, et al.
Published: (2013)

Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy
by: Tomas Smolek, et al.
Published: (2019-12-01)

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.
by: Hongjun Fu, et al.
Published: (2016-01-01)

Permeability of Proteins at the Blood–Brain Barrier in the Normal Adult Mouse and Double Transgenic Mouse Model of Alzheimer's Disease
by: Joseph F. Poduslo, et al.
Published: (2001-08-01)

Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
by: Manuel Schweighauser, et al.
Published: (2023-10-01)

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease.
by: Yazi D Ke, et al.
Published: (2009-11-01)

Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
by: M.A Kurt, et al.
Published: (2003-10-01)

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.
by: Brownlees, J, et al.
Published: (1997)

T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice.
by: Bachmann, M, et al.
Published: (1994)

Corrigendum: Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy
by: Tomas Smolek, et al.
Published: (2020-02-01)

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord
by: Jennifer A. Macdonald, et al.
Published: (2019-03-01)

Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice
by: Antonio Valencia, et al.
Published: (2021-06-01)

Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies
by: Kazuya Tsumagari, et al.
Published: (2022-08-01)

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
by: Jing Di, et al.
Published: (2021-01-01)

Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
by: Francesca Vitale, et al.
Published: (2020-08-01)

Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice
by: Zhiva Skachokova, et al.
Published: (2019-05-01)

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
by: Abisambra Jose F, et al.
Published: (2010-11-01)

Deficiency of NLRP3 protects cerebral pericytes and attenuates Alzheimer’s pathology in tau-transgenic mice
by: Wenqiang Quan, et al.
Published: (2024-10-01)

AD-TAU INDUCED TANGLE-LIKE PATHOLOGY IN A NEWLY CHARACTERIZED TRANSGENIC MOUSE MODEL
by: Muhammad Khalid Muhammadi, et al.
Published: (2023-10-01)

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
by: Karim Belarbi, et al.
Published: (2011-08-01)

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
by: Jing Di, et al.
Published: (2021-04-01)

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
by: Janice C. Malcolm, et al.
Published: (2019-07-01)

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
by: Rinie Bajracharya, et al.
Published: (2021-03-01)

Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in Caenorhabditis elegans
by: Marina Han, et al.
Published: (2024-03-01)

Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies.
by: Cristina d'Abramo, et al.
Published: (2015-01-01)

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology
by: Mar Matarin, et al.
Published: (2015-02-01)

CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease
by: Jeremy Koppel, et al.
Published: (2013-10-01)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
by: Sarah Houben, et al.
Published: (2020-07-01)

Regulation of utrophin in transgenic mice.
by: Davies, K
Published: (2005)

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice
by: Céline Héraud, et al.
Published: (2014-02-01)

Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
by: Holly J Garringer, et al.
Published: (2013-01-01)

Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.
by: Natalie D Bull, et al.
Published: (2012-01-01)

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
by: Hong Wang, et al.
Published: (2018-12-01)