Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype

Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype

Abstract The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability. Glaucoma, a neurodegenerative disorder affecting the reti...

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Main Authors: Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A. Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L. Graham, Vivek Gupta
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Acta Neuropathologica Communications
Subjects:
Glaucoma
Tau
Retinal ganglion cells
Microtubules
Neurodegeneration
Intraocular pressure
Online Access:https://doi.org/10.1186/s40478-024-01804-0

Internet

https://doi.org/10.1186/s40478-024-01804-0

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