CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Negative immune regulation plays a notable role in tumor immunity. This study aimed to confirm that CD137 mediates negative immunoregulation as well as agonist activity in tumor immunity. Soluble CD137 (sCD137), a prominent splice variant of membrane-bound CD137 (mCD137), was identified, and its con...

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Bibliographic Details
Main Authors: Ling Yi, Xin Jin, Jinghui Wang, Zhuohong Yan, Xu Cheng, Tao Wen, Bin Yang, Xiaojue Wang, Nanying Che, Zhidong Liu, Hongtao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
lung cancer
sCD137
CD137+ Tregs
negative regulation
CD137 agonist
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.771809/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.771809/full

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