The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro model of liver disease. C2C12 myotubes were serum and amino acid starved for 1-h and s...

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Bibliographic Details
Main Authors: Sophie L. Allen, Alex P. Seabright, Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
chronic liver disease
sarcopenia
leucine
mitochondria
protein breakdown
Online Access:https://www.mdpi.com/2073-4409/11/7/1098

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https://www.mdpi.com/2073-4409/11/7/1098

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