Gene-guided OX40L anchoring to tumor cells for synergetic tumor “self-killing” immunotherapy

Gene-guided OX40L anchoring to tumor cells for synergetic tumor “self-killing” immunotherapy

The low objective response rates and severe side effects largely limit the clinical outcomes of immune checkpoint blockade (ICB) therapy. Here, a tumor “self-killing” therapy based on gene-guided OX40L anchoring to tumor cell membrane was reported to boost ICB therapy. We developed a highly efficien...

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Bibliographic Details
Main Authors: Lin Lin, Yingying Hu, Zhaopei Guo, Jie Chen, Pingjie Sun, Huayu Tian, Xuesi Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-07-01
Series:Bioactive Materials
Subjects:
OX40L anchoring to tumor cell membrane
Gene engineering
Tumor immunotherapy
Anti-PD therapy
Tumor relapse and metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22003073

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http://www.sciencedirect.com/science/article/pii/S2452199X22003073

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