Comparison of replication-competent, first generation, and helper-dependent adenoviral vaccines.

All studies using human serotype 5 Adenovirus (Ad) vectors must address two major obstacles: safety and the presence of pre-existing neutralizing antibodies. Helper-Dependent (HD) Ads have been proposed as alternative vectors for gene therapy and vaccine development because they have an improved saf...

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Bibliographic Details
Main Authors: Eric A Weaver, Pramod N Nehete, Stephanie S Buchl, Julien S Senac, Donna Palmer, Philip Ng, K Jagannadha Sastry, Michael A Barry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2659436?pdf=render