D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design

D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design

In the O1 strain of Klebsiella, the lipopolysaccharide (LPS) O-antigen is composed of D-galactan I and D-galactan II. Although the composition of the O1 antigen of Klebsiella was resolved more than two decades, the genetic locus involved in the biosynthesis of D-galactan II and the role of D-galacta...

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Bibliographic Details
Main Authors: Pei-Fang eHsieh, Meng-Chuan eWu, Feng-Ling eYang, Chun-Tang eChen, Tzu-Chi eLou, Yi-Yin eChen, Shih-Hsiung eWu, Jin-Chuan eSheu, Jin-Town eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
lipopolysaccharide
Vaccine
D-galactan II
immunodominant antigen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00608/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00608/full

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