Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer

Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer

Abstract Background Next-Generation Sequencing (NGS)-based testing in cancer patients has led to increased detection of variants of uncertain significance (VUS). VUS are genetic variants whose impact on protein function is unknown. VUS pose a challenge to clinicians and patients due to uncertainty r...

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Bibliographic Details
Main Authors: Kawmadi Gunawardena, Nirmala D. Sirisena, Gayani Anandagoda, Nilaksha Neththikumara, Vajira H.W. Dissanayake
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Research Notes
Subjects:
Breast cancer
cancer phenotype
Germline variants
Hereditary cancer
VUS
Online Access:https://doi.org/10.1186/s13104-023-06365-4

Internet

https://doi.org/10.1186/s13104-023-06365-4

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