Germline variants of uncertain significance, their frequency, and clinico-pathological features in a cohort of Sri Lankan patients with hereditary breast cancer
Abstract Background Next-Generation Sequencing (NGS)-based testing in cancer patients has led to increased detection of variants of uncertain significance (VUS). VUS are genetic variants whose impact on protein function is unknown. VUS pose a challenge to clinicians and patients due to uncertainty r...
Main Authors: | Kawmadi Gunawardena, Nirmala D. Sirisena, Gayani Anandagoda, Nilaksha Neththikumara, Vajira H.W. Dissanayake |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-06-01
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Series: | BMC Research Notes |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13104-023-06365-4 |
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