Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation

Abstract Cyclic di-AMP is the only known essential second messenger in bacteria and archaea, regulating different proteins indispensable for numerous physiological processes. In particular, it controls various potassium and osmolyte transporters involved in osmoregulation. In Bacillus subtilis, the...

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Bibliographic Details
Main Authors: Michael F. Fuss, Jan-Philip Wieferig, Robin A. Corey, Yvonne Hellmich, Igor Tascón, Joana S. Sousa, Phillip J. Stansfeld, Janet Vonck, Inga Hänelt
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38944-1