The Protease Domain in HEV pORF1 Mediates the Replicase’s Localization to Multivesicular Bodies and Its Exosomal ReleaseSummary

The Protease Domain in HEV pORF1 Mediates the Replicase’s Localization to Multivesicular Bodies and Its Exosomal ReleaseSummary

Background: A peculiar feature of the hepatitis E virus (HEV) is its reliance on the exosomal route for viral release. Genomic replication is mediated via the viral polyprotein pORF1, yet little is known about its subcellular localization. Methods: Subcellular localization of pORF1 and its subdomain...

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Bibliographic Details
Main Authors: Mirco Glitscher, Inga Mareike Spannaus, Fabiane Behr, Robin Oliver Murra, Kathrin Woytinek, Daniela Bender, Eberhard Hildt
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
PCP
Exosomes
Viral Replication
Viral Spread
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X24000018

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http://www.sciencedirect.com/science/article/pii/S2352345X24000018

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