Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4
Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33277-x |
| _version_ | 1811200847116238848 |
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| author | Qiang Luo Jiezhen Mo Hao Chen Zetao Hu Baihui Wang Jiabing Wu Ziyu Liang Wenhao Xie Kangxi Du Maolin Peng Yingping Li Tianyang Li Yangyi Zhang Xiaoyan Shi Wen-Hui Shen Yang Shi Aiwu Dong Hailin Wang Jinbiao Ma |
| author_facet | Qiang Luo Jiezhen Mo Hao Chen Zetao Hu Baihui Wang Jiabing Wu Ziyu Liang Wenhao Xie Kangxi Du Maolin Peng Yingping Li Tianyang Li Yangyi Zhang Xiaoyan Shi Wen-Hui Shen Yang Shi Aiwu Dong Hailin Wang Jinbiao Ma |
| author_sort | Qiang Luo |
| collection | DOAJ |
| description | Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis. |
| first_indexed | 2024-04-12T02:10:38Z |
| format | Article |
| id | doaj.art-d7e9bd71e1d445358d61364011637fbe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T02:10:38Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d7e9bd71e1d445358d61364011637fbe2022-12-22T03:52:24ZengNature PortfolioNature Communications2041-17232022-09-0113111110.1038/s41467-022-33277-xStructural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4Qiang Luo0Jiezhen Mo1Hao Chen2Zetao Hu3Baihui Wang4Jiabing Wu5Ziyu Liang6Wenhao Xie7Kangxi Du8Maolin Peng9Yingping Li10Tianyang Li11Yangyi Zhang12Xiaoyan Shi13Wen-Hui Shen14Yang Shi15Aiwu Dong16Hailin Wang17Jinbiao Ma18State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of SciencesDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and TechnologyState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and TechnologyDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and TechnologyState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityLudwig Institute for Cancer Research, Oxford UniversityState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, International Associated Laboratory of CNRS-Fudan-HUNAU on Plant Epigenome Research, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Chinese Academy of SciencesState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, Institute of Plant Biology, School of Life Sciences, Fudan UniversityHere the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.https://doi.org/10.1038/s41467-022-33277-x |
| spellingShingle | Qiang Luo Jiezhen Mo Hao Chen Zetao Hu Baihui Wang Jiabing Wu Ziyu Liang Wenhao Xie Kangxi Du Maolin Peng Yingping Li Tianyang Li Yangyi Zhang Xiaoyan Shi Wen-Hui Shen Yang Shi Aiwu Dong Hailin Wang Jinbiao Ma Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 Nature Communications |
| title | Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 |
| title_full | Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 |
| title_fullStr | Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 |
| title_full_unstemmed | Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 |
| title_short | Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 |
| title_sort | structural insights into molecular mechanism for n 6 adenosine methylation by mt a70 family methyltransferase mettl4 |
| url | https://doi.org/10.1038/s41467-022-33277-x |
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