Cullin-5 Adaptor SPSB1 Controls NF-κB Activation Downstream of Multiple Signaling Pathways

Cullin-5 Adaptor SPSB1 Controls NF-κB Activation Downstream of Multiple Signaling Pathways

The initiation of innate immune responses against pathogens relies on the activation of pattern-recognition receptors (PRRs) and corresponding intracellular signaling cascades. To avoid inappropriate or excessive activation of PRRs, these responses are tightly controlled. Cullin-RING E3 ubiquitin li...

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Bibliographic Details
Main Authors: Iliana Georgana, Carlos Maluquer de Motes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
SPSB1
Cullins
NF-κB
innate immunity
inflammation
signal transduction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03121/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03121/full

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