Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination

Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination

Abstract Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the vasculature. An integrative ubiquitinome and pr...

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Bibliographic Details
Main Authors: Raj N. Sewduth, Paolo Carai, Tonci Ivanisevic, Mingzhen Zhang, Hyunbum Jang, Benoit Lechat, Delphi Van Haver, Francis Impens, Ruth Nussinov, Elizabeth Jones, Anna Sablina
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
endothelial cells
GTPase
mechanobiology
spatial OMICs
ubiquitin system
Online Access:https://doi.org/10.1002/advs.202303367

Internet

https://doi.org/10.1002/advs.202303367

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