Bispecific Antibodies for IFN-β Delivery to ErbB2<sup>+</sup> Tumors

Bispecific Antibodies for IFN-β Delivery to ErbB2<sup>+</sup> Tumors

The main aim of our work was to create a full-length bispecific antibody (BsAb) as a vehicle for the targeted delivery of interferon-beta (IFN-β) to ErbB2<sup>+</sup> tumor cells in the form of non-covalent complex of BsAb and IFN-β. Such a construct is a CrossMab-type BsAb, consisting o...

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Bibliographic Details
Main Authors: Vladislav S. Rybchenko, Anna A. Panina, Teimur K. Aliev, Olga N. Solopova, Dmitry S. Balabashin, Valery N. Novoseletsky, Dmitry A. Dolgikh, Petr G. Sveshnikov, Mikhail P. Kirpichnikov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
ErbB2
IFN-β
bispecific antibody
Online Access:https://www.mdpi.com/2218-273X/11/12/1915

Internet

https://www.mdpi.com/2218-273X/11/12/1915

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