Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

Summary: Recent single-cell analyses have revealed the complexity of microglial heterogeneity in brain development, aging, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Disease-associated microglia (DAMs) have been identified in ALS mice model, but their role in ALS pat...

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Bibliographic Details
Main Authors: Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, Koji Yamanaka
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Genetics
Neuroscience
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000932

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http://www.sciencedirect.com/science/article/pii/S2589004224000932

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