Brain Region Differences in α1- and α5-Subunit-Containing GABA<sub>A</sub> Receptor Proteomes Revealed with Affinity Purification and Blue Native PAGE Proteomics

GABA<sub>A</sub> receptors are the major inhibitory receptors in the brain. They are hetero-pentamers with a composition of predominantly two α, two β, and one γ or δ subunit. Of the six α subunit genes, the α5 subunit displays a limited spatial expression pattern and is known to mediate...

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Bibliographic Details
Main Authors: Miao Chen, Frank Koopmans, Miguel A. Gonzalez-Lozano, August B. Smit, Ka Wan Li
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/13/1/14