Cancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy

Cancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy

Abstract Background Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance to ICD-inducing chemotherapeuti...

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Bibliographic Details
Main Authors: Jinseong Kim, Man Kyu Shim, Yujeong Moon, Jeongrae Kim, Hanhee Cho, Wan Su Yun, Nayeon Shim, Joon-Kyung Seong, Yonghyun Lee, Dong-Kwon Lim, Kwangmeyung Kim
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Nanobiotechnology
Subjects:
Aposomes
Cancer immunotherapy
Immune checkpoint blockade
PEGylated liposome
Immunogenic cell death
Drug resistance
Online Access:https://doi.org/10.1186/s12951-024-02314-w

Internet

https://doi.org/10.1186/s12951-024-02314-w

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