Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity

Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity

Despite the availability of the current drug arsenal for pain management, there is still a clinical need to identify new, more effective, and safer analgesics. Based on our earlier study, newly synthesized 1,3,4-oxadiazole derivatives of pyrrolo[3,4-<i>d</i>]pyridazinone, especially <...

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Bibliographic Details
Main Authors: Marta Szandruk-Bender, Benita Wiatrak, Łukasz Szczukowski, Piotr Świątek, Maria Rutkowska, Stanisław Dzimira, Anna Merwid-Ląd, Maciej Danielewski, Adam Szeląg
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
pain
tail-flick test
formalin test
pyrrolo[3,4-<i>d</i>]pyridazinone
1,3,4-oxadiazole
Online Access:https://www.mdpi.com/1422-0067/21/24/9685

Internet

https://www.mdpi.com/1422-0067/21/24/9685

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