Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury

Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury

Ischemic stroke causes neuronal cell death and triggers a cascade of inflammatory signals that contribute to secondary brain damage. Microglia, the brain-resident macrophages that remove dead neurons, play a critical role in the brain’s response to ischemic injury. Our previous studies showed that I...

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Bibliographic Details
Main Authors: Shelly A. Cruz, Aswin Hari, Zhaohong Qin, Pascal Couture, Hua Huang, Diane C. Lagace, Alexandre F. R. Stewart, Hsiao-Huei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ischemic brain injury
inflammation
microglia
interferon beta
sensory-motor function
photothrombosis
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00201/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00201/full

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