Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties

Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties

Abstract A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkylsulfonyl)-3,5-bis(ylidene)-piperidin-4-ones 3a‒h. X-ray diffraction studies (6...

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Bibliographic Details
Main Authors: Nehmedo G. Fawazy, Siva S. Panda, Ahmed Mostafa, Benson M. Kariuki, Mohamed S. Bekheit, Yassmin Moatasim, Omnia Kutkat, Walid Fayad, May A. El-Manawaty, Ahmed A. F. Soliman, Riham A. El-Shiekh, Aladdin M. Srour, Reham F. Barghash, Adel S. Girgis
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17883-9

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https://doi.org/10.1038/s41598-022-17883-9

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