IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis

IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the role of UBASH3A in RA pathogenesis, by assessing the role of super-enhan...

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Bibliographic Details
Main Authors: Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Anh Phuong Nguyen, Naoyuki Ohkubo, Shigeru Iwata, Shigeaki Kato, Yoshiya Tanaka
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Inflammation and Regeneration
Subjects:
Rheumatoid arthritis
CD4
Super-enhancer
UBASH3A
IL-6
Online Access:https://doi.org/10.1186/s41232-022-00231-9

Internet

https://doi.org/10.1186/s41232-022-00231-9

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