IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis
Abstract Background Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the role of UBASH3A in RA pathogenesis, by assessing the role of super-enhan...
Main Authors: | Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Anh Phuong Nguyen, Naoyuki Ohkubo, Shigeru Iwata, Shigeaki Kato, Yoshiya Tanaka |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-11-01
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Series: | Inflammation and Regeneration |
Subjects: | |
Online Access: | https://doi.org/10.1186/s41232-022-00231-9 |
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