Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation. Donor T cell addback can accelerate immune reconstitution but the therapeutic window between graft-vs.-ho...

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Bibliographic Details
Main Authors: Ping Zhang, Siok-Keen Tey
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
haploidentical transplant
T cell immune reconstitution
adoptive T cell therapy
antigen-specific T cells
safety switch
gene modification
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01854/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01854/full

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