Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Adoptive T Cell Therapy Following Haploidentical Hematopoietic Stem Cell Transplantation

Delayed immune reconstitution and the consequently high rates of leukemia relapse and infectious complications are the main limitations of haploidentical hematopoietic stem cell transplantation. Donor T cell addback can accelerate immune reconstitution but the therapeutic window between graft-vs.-ho...

Full description

Bibliographic Details
Main Authors:	Ping Zhang, Siok-Keen Tey
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-08-01
Series:	Frontiers in Immunology
Subjects:	haploidentical transplant T cell immune reconstitution adoptive T cell therapy antigen-specific T cells safety switch gene modification
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01854/full

Similar Items

Editorial: The Immunobiology of HLA-Haploidentical Hematopoietic Cell Transplantation
by: Antonella Mancusi, et al.
Published: (2020-05-01)

Functional Reconstitution Of Natural Killer Cells In Allogeneic Hematopoietic Stem Cell Transplantation
by: Md Ashik eUllah, et al.
Published: (2016-04-01)

Influence of ABO compatibility on haploidentical hematopoietic stem-cell transplant
by: Rajesh B Sawant, et al.
Published: (2023-01-01)

CMV Infection and CMV-Specific Immune Reconstitution Following Haploidentical Stem Cell Transplantation: An Update
by: Xiao-Hua Luo, et al.
Published: (2021-10-01)

Innate Immune Responses in the Outcome of Haploidentical Hematopoietic Stem Cell Transplantation to Cure Hematologic Malignancies
by: Elisa Zaghi, et al.
Published: (2019-11-01)

Persistence of KIRneg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation
by: Clara Di Vito, et al.
Published: (2024-01-01)

Post-transplant cyclophosphamide or cell selection in haploidentical allogeneic hematopoietic cell transplantation?
by: Razan Mohty, et al.
Published: (2024-12-01)

Immune Reconstitution after Haploidentical Donor and Umbilical Cord Blood Allogeneic Hematopoietic Cell Transplantation
by: Hany Elmariah, et al.
Published: (2021-01-01)

Strategies in Haploidentical Stem Cell Transplantation in Adults
by: Ulaş D. Bayraktar, et al.
Published: (2013-12-01)

The Evolution of T Cell Depleted Haploidentical Transplantation
by: Franco Aversa, et al.
Published: (2019-11-01)

Haploidentical Stem Cell Transplantation in Children With Hematological Malignancies Using αβ+ T-Cell Receptor and CD19+ Cell Depleted Grafts: High CD56dim/CD56bright NK Cell Ratio Early Following Transplantation Is Associated With Lower Relapse Incidence and Better Outcome
by: Miguel A. Diaz, et al.
Published: (2019-10-01)

Current status of conditioning regimens in haploidentical hematopoietic cell transplantation
by: Junichi Sugita, et al.
Published: (2024-12-01)

T-Cell Depleted Haploidentical Transplantation in Children With Hematological Malignancies: A Comparison Between CD3+/CD19+ and TCRαβ+/CD19+ Depletion Platforms
by: Marta Gonzalez-Vicent, et al.
Published: (2022-06-01)

Delayed kidney transplantation after HLA-haploidentical hematopoietic cell transplantation in a young woman with myelodysplastic syndrome with renal failure
by: Kevin C. Miller, et al.
Published: (2022-01-01)

Haploidentical Hematopoietic Cell Transplantation Using Posttransplant Cyclophosphamide for Sézary Syndrome
by: Madoka Kanda-Kato, et al.
Published: (2020-09-01)

Haploidentical hematopoietic stem cell transplantation in a myelofibrosis patient with primary graft failure
by: Cristina Tecchio, et al.
Published: (2018-01-01)

New‐onset posttransplant diabetes mellitus after haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide
by: Brendan L. Mangan, et al.
Published: (2020-11-01)

Haploidentical Stem Cell Transplantation in Lymphomas—Expectations and Pitfalls
by: Jacopo Mariotti, et al.
Published: (2020-11-01)

Case report: First report of haploidentical allogeneic hematopoietic stem cell transplantation from donors with mild alpha-thalassemia for acute leukemia
by: Wenshuai Zheng, et al.
Published: (2022-12-01)

Desensitization with plasma exchange in a patient with human leukocyte antigen donor-specific antibodies before T-cell-replete haploidentical hematopoietic stem cell transplantation
by: Rasika Dhawan Setia, et al.
Published: (2019-01-01)

First Successful Haploidentical Stem Cell Transplantation in Romania
by: Tănase Alina, et al.
Published: (2016-09-01)

No differences in hemostatic and endothelial activations between haploidentical and matched-donor hematopoietic stem cell transplantation in thalassemia disease
by: Surapong Lertthammakiat, et al.
Published: (2020-09-01)

Effects of anti-HLA donor-specific antibodies and desensitization on engraftment of haploidentical hematopoietic stem cell transplantation
by: MA Yao, et al.
Published: (2024-02-01)

Increased risk of 100-day and 1-year infection-related mortality and complications in haploidentical stem cell transplantation
by: Chang J, et al.
Published: (2019-05-01)

Repeated haploidentical allogeneic hematopoietic stem cell transplantation with TCR αβ/CD19 depletion in patient with primary myelofibrosis. Case report
by: Elmira I. Kolgaeva, et al.
Published: (2021-07-01)

Combination of Haploidentical Hematopoietic Stem Cell Transplantation with Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Severe Aplastic Anemia: A Retrospective Controlled Study
by: Xian-fu Sheng, et al.
Published: (2022-05-01)

Haploidentical stem cell transplant: Established treatment, expanding horizons
by: Mukul Aggarwal, et al.
Published: (2016-01-01)

Impact of donor-specific anti-human leukocyte antigen antibodies in haploidentical hematopoietic stem-cell transplantation: A single-center retrospective study
by: Rajesh B Sawant, et al.
Published: (2022-01-01)

Debating the Future of Sickle Cell Disease Curative Therapy: Haploidentical Hematopoietic Stem Cell Transplantation vs. Gene Therapy
by: Adetola A. Kassim, et al.
Published: (2022-08-01)

Human Leukocyte Antigen–Haploidentical Haematopoietic Stem Cell Transplantation Using Post-Transplant Cyclophosphamide for Paediatric Haematological Malignancies
by: Takuro Nishikawa
Published: (2024-01-01)

Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide for T-Cell Prolymphocytic Leukemia after Alemtuzumab Induction Therapy: A Case Report
by: Naoki Okada, et al.
Published: (2023-08-01)

Donor specific HLA antibody in hematopoietic stem cell transplantation: Implications for donor selection
by: Scott M. Krummey, et al.
Published: (2022-08-01)

A Predicted Model for Refractory/Recurrent Cytomegalovirus Infection in Acute Leukemia Patients After Haploidentical Hematopoietic Stem Cell Transplantation
by: Meng-Zhu Shen, et al.
Published: (2022-03-01)

Real‐world experience: Introduction of T cell replete haploidentical transplantations in a single center
by: Gwendolyn vanGorkom, et al.
Published: (2021-08-01)

Anti-hla donor-specific antibodies are associated to infection and not to the engraftment rate in outpatient haploidentical hematopoietic cell transplantation
by: José C. Jaime-Pérez, et al.
Published: (2023-01-01)

Haploidentical Hematopoietic Stem Cell Transplantation Followed by ‘Post-Cyclophosphamide’: The Future of Allogeneic Stem Cell Transplant
by: Samuel Cytryn, et al.
Published: (2020-04-01)

Intensified conditioning regimen with fludarabine combined with post-transplantation cyclophosphamide for haploidentical allogeneic hematopoietic stem cell transplantation in children with high-risk acute leukemia
by: Junjie Cao, et al.
Published: (2023-12-01)

Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas
by: Thomas Eichholz, et al.
Published: (2023-02-01)

Editorial: Advances in Pediatric Hematopoietic Cell Therapies and Transplantation
by: Emmanuel Katsanis, et al.
Published: (2022-01-01)

Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation
by: Alice Bertaina, et al.
Published: (2019-07-01)