The Impact of Single Nucleotide Polymorphisms on the Pharmacokinetics of Tacrolimus in Kidney Allograft Recipients of Northern-West, Iran

The Impact of Single Nucleotide Polymorphisms on the Pharmacokinetics of Tacrolimus in Kidney Allograft Recipients of Northern-West, Iran

Purpose: Calcineurin inhibitors (CNIs) such as tacrolimus are a major immunosuppressive therapy after renal transplantation, which inhibit cytokine expression. The pharmacokinetics of such drugs is influenced by cytochrome P450 (CYP) enzymes, multi-drug resistance-1 (MDR-1), and C25385T pregnane X r...

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Bibliographic Details
Main Authors: Elaheh Jabbari Hagh, Ali Mousavi, Seyyedeh Mina Hejazian, Mehdi Haghi, Samaneh Esfahanian, Elham Ahmadian, Sepideh Zununi Vahed, Mohammadreza Ardalan
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2023-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
cyp 3a5 gene
polymorphism
tacrolimus
kidney transplantation
pxr gene
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-13-393.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-13-393.pdf

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