Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition

Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition

Abstract Background Cyclooxygenase 2 (COX-2) promotes stemness in triple negative breast cancer (TNBC), highlighting COX-2 as a promising therapeutic target in these tumors. However, to date, clinical trials using COX-2 inhibitors in breast cancer only showed variable patient responses with no clear...

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Bibliographic Details
Main Authors: Jun Tian, Vivian Wang, Ni Wang, Baharak Khadang, Julien Boudreault, Khldoun Bakdounes, Suhad Ali, Jean-Jacques Lebrun
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Breast Cancer Research
Subjects:
COX-2
Celecoxib
Breast cancer
TNBC
Drug resistance
MGFE8
Online Access:https://doi.org/10.1186/s13058-021-01401-2

Internet

https://doi.org/10.1186/s13058-021-01401-2

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