The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting enzyme that metabolizes an essential amino acid tryptophan (Trp) into kynurenine (Kyn), and it promotes the occurrence of immunosuppressive effects by regulating the consumption of Trp and the accumulation of Kyn in the tumor microenvironment...

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Bibliographic Details
Main Authors: Xinting Huang, Feng Zhang, Xiaobo Wang, Ke Liu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
indoleamine 2,3-dioxygenase 1
tumor microenvironment
interferon-γ
dendritic cell
myeloid-derived suppressor cell
regulatory T cell
Online Access:https://www.mdpi.com/2072-6694/14/11/2756

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https://www.mdpi.com/2072-6694/14/11/2756

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