Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Sphingosine 1-phosphate (S1P) lyase (SPL, <i>Sgpl1</i>) is an ER-associated enzyme that irreversibly degrades the bioactive lipid, S1P, and thereby regulates multiple cellular functions attributed to S1P. Biallelic mutations in the human <i>Sglp1</i> gene lead to a severe for...

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Bibliographic Details
Main Authors: Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Hermann Pavenstädt, Josef Pfeilschifter, Andrea Huwiler
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine 1-phosphate
sphingosine 1-phosphate lyase
glomerular disease
nephrotic syndrome
podocytes
Wilms tumor suppressor gene 1
Online Access:https://www.mdpi.com/1422-0067/24/4/3267

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https://www.mdpi.com/1422-0067/24/4/3267

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