Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis.

Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis.

Tumor necrosis factor α (TNF-α) is a key regulator of inflammation and rheumatoid arthritis (RA). TNF-α blocker therapies can be very effective for a substantial number of patients, but fail to work in one third of patients who show no or minimal response. It is therefore necessary to discover new m...

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Bibliographic Details
Main Authors: Heming Xing, Paul D McDonagh, Jadwiga Bienkowska, Tanya Cashorali, Karl Runge, Robert E Miller, Dave Decaprio, Bruce Church, Ronenn Roubenoff, Iya G Khalil, John Carulli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3053315?pdf=render

Internet

http://europepmc.org/articles/PMC3053315?pdf=render

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