The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway

The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway

Lag periods of therapeutic efficacy cause poor compliance of patients, which has made solutions for rapid antidepressants the most urgent need in the depression study field at present. We have identified through our previous studies the rapid antidepressant effects of the traditional herb Gardenia j...

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Bibliographic Details
Main Authors: Li Ren, Hailou Zhang, Weiwei Tao, Yin Chen, Zhilu Zou, XiaoYan Guo, Qinqin Shen, Quansheng Feng, Jingqing Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
Gardenia jasminoides Ellis
iridoid fraction
rapid and enduring antidepressant
PKA
CREB
BDNF
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.896628/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.896628/full

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