Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

Genetic optimization of Nucleic Acid immunogens is important for potentially improving their immune potency. A COVID-19 DNA vaccine is in phase III clinical trial which is based on a promising highly developable technology platform. Here, we show optimization in mice generating a pGX-9501 DNA vaccin...

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Bibliographic Details
Main Authors: Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B. Weiner, Kate Broderick, Bin Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
sars-cov-2
covid-19
spike protein
dna vaccine
protective response
wild-type sequence
optimizations
Online Access:http://dx.doi.org/10.1080/21645515.2021.2016201

Internet

http://dx.doi.org/10.1080/21645515.2021.2016201

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