Genetic Analysis of <i>ABCB4</i> Mutations and Variants Related to the Pathogenesis and Pathophysiology of Low Phospholipid-Associated Cholelithiasis

Genetic Analysis of <i>ABCB4</i> Mutations and Variants Related to the Pathogenesis and Pathophysiology of Low Phospholipid-Associated Cholelithiasis

Clinical studies have revealed that the <i>ABCB4</i> gene encodes the phospholipid transporter on the canalicular membrane of hepatocytes, and its mutations and variants are the genetic basis of low phospholipid-associated cholelithiasis (LPAC), a rare type of gallstone disease caused by...

Full description

Bibliographic Details
Main Authors: Helen H. Wang, Piero Portincasa, Min Liu, David Q.-H. Wang
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Genes
Subjects:
ABC transporters
bile acids
bile flow
bile formation
biliary lipid secretion
cholesterol crystallization
Online Access:https://www.mdpi.com/2073-4425/13/6/1047

Internet

https://www.mdpi.com/2073-4425/13/6/1047

Similar Items