Persistence of Mycobacterium tuberculosis in response to infection burden and host-induced stressors

IntroductionAs infection with Mycobacterium tuberculosis progresses, the bacilli experience various degrees of host stressors in the macrophage phagosome such as low pH, nutrient deprivation, or exposure to toxic agents, which promotes cell-to-cell phenotypic variation. This includes a physiological...

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Bibliographic Details
Main Authors: Trisha Parbhoo, Haiko Schurz, Jacoba M. Mouton, Samantha L. Sampson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.981827/full