Absence of Uncoupling Protein-3 at Thermoneutrality Impacts Lipid Handling and Energy Homeostasis in Mice

Absence of Uncoupling Protein-3 at Thermoneutrality Impacts Lipid Handling and Energy Homeostasis in Mice

The role of uncoupling protein-3 (UCP3) in energy and lipid metabolism was investigated. Male wild-type (WT) and UCP3-null (KO) mice that were housed at thermoneutrality (30 °C) were used as the animal model. In KO mice, the ability of skeletal muscle mitochondria to oxidize fatty acids (bu...

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Bibliographic Details
Main Authors: Assunta Lombardi, Rosa Anna Busiello, Rita De Matteis, Lillà Lionetti, Sabrina Savarese, Maria Moreno, Alessandra Gentile, Elena Silvestri, Rosalba Senese, Pieter de Lange, Federica Cioffi, Antonia Lanni, Fernando Goglia
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
uncoupling protein
mitochondria: energy metabolism
lipid handling
fatty acid oxidation
Online Access:https://www.mdpi.com/2073-4409/8/8/916

Internet

https://www.mdpi.com/2073-4409/8/8/916

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