Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)

Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)

Abstract Background Shiga toxin-producing E. coli (STEC) infections affect children and adults worldwide, and treatment remain solely supportive. Up to 15–20% of children infected by high-risk STEC (i.e., E. coli that produce Shiga toxin 2) develop hemolytic anemia, thrombocytopenia, and kidney fail...

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Bibliographic Details
Main Authors: Stephen B. Freedman, David Schnadower, Myka Estes, T. Charles Casper, Stuart L. Goldstein, Silviu Grisaru, Andrew T. Pavia, Benjamin S. Wilfond, Melissa Metheney, Kadyn Kimball, Phillip I. Tarr, On behalf of the Hyperhydration to Improve Kidney Outcomes in children with Shiga Toxin-producing E. Coli infection (HIKO-STEC) Study Team
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Trials
Subjects:
Shiga toxin-producing E. coli (STEC)
Hemolytic uremic syndrome (HUS)
Hyperhydration
Euvolemia
Children
Gastroenteritis
Online Access:https://doi.org/10.1186/s13063-023-07379-w

Internet

https://doi.org/10.1186/s13063-023-07379-w

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