Defucosylated Monoclonal Antibody (H<sub>2</sub>Mab-139-mG<sub>2a</sub>-f) Exerted Antitumor Activities in Mouse Xenograft Models of Breast Cancers against Human Epidermal Growth Factor Receptor 2

Defucosylated Monoclonal Antibody (H<sub>2</sub>Mab-139-mG<sub>2a</sub>-f) Exerted Antitumor Activities in Mouse Xenograft Models of Breast Cancers against Human Epidermal Growth Factor Receptor 2

The clinically approved human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibodies (mAbs), trastuzumab, and pertuzumab, target domains IV and II, respectively. Trastuzumab is now the standard treatment for HER2-overexpressed breast and gastric cancers, and trastuzumab in combina...

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Bibliographic Details
Main Authors: Hiroyuki Suzuki, Tomokazu Ohishi, Ren Nanamiya, Manabu Kawada, Mika K. Kaneko, Yukinari Kato
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Current Issues in Molecular Biology
Subjects:
antibody-dependent cellular cytotoxicity
breast cancer
HER2
monoclonal antibody
antitumor activities
mouse tumor model
Online Access:https://www.mdpi.com/1467-3045/45/10/488

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https://www.mdpi.com/1467-3045/45/10/488

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