MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the nucleus where it regulates a wide range of genes in response to metabolic dysfunction. It is colocalized to mitochondria in vari...

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Bibliographic Details
Main Authors: Zahra Mohtashami, Mithalesh K. Singh, Nasim Salimiaghdam, Mustafa Ozgul, M. Cristina Kenney
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
MOTS-c
mitochondrial derived peptides
mitochondrial dysfunction
aging
age-related diseases
Online Access:https://www.mdpi.com/1422-0067/23/19/11991

Internet

https://www.mdpi.com/1422-0067/23/19/11991

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