Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease

Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease

Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models. However, several studies have demonstrated that human CD4+ T conventional (Tconv) cells activated in vitro by T cell receptor (TCR)...

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Bibliographic Details
Main Authors: Lyra Morina, Madalyn E. Jones, Cihan Oguz, Mariana J. Kaplan, Arunakumar Gangaplara, Courtney D. Fitzhugh, Christopher G. Kanakry, Ethan M. Shevach, Maja Buszko
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell
Foxp3
Helios
SLE
GVHD
SLe
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114780/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114780/full

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