Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.

Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium.

During vertebrate eye development, the transcription factor MITF acts to promote the development of the retinal pigment epithelium (RPE). In embryos with Mitf mutations, the future RPE hyperproliferates and is respecified as retinal tissue but only in a small portion of the dorsal RPE. Using a serie...

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Bibliographic Details
Main Authors: Jingxing Ou, Kapil Bharti, Alessandro Nodari, Stefano Bertuzzi, Heinz Arnheiter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3598659?pdf=render

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http://europepmc.org/articles/PMC3598659?pdf=render

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